A repeat expansion in the C9orf72 gene is the most frequent cause of ALS and FTD. Researchers from Max Planck Institute of Biochemistry and University Medical Center Gröningen revealed the molecular mechanism behind Dipeptide Repeat Proteins (DRP) cytotoxicity in their publication in the journal eLife. They used Amytracker 680 to localize and characterize both cytoplasmic and nuclear DRP aggregates.

Image:🔬HEK293 cells transfected with the indicated constructs and labeled with Amytracker 680. (AmyT in red, Poly-GA DPRs in green, nuclear membrane indicated by white dashed lines). Frottin et al. (Fig. 1D) (CC BY 4.0)