β-2-microglobulin is a protein present in all nucleated cells and is elevated in many tumors or inflammatory diseases. It is well known that the protein has a propensity for aggregation. A study published in the journal Immunity by Hofbauer et al. has investigated the role of β-2-microglobulin aggregates on the activation of inflammatory processes in Multiple Myeloma. Amtracker 480 has been used in the study to detect amyloid aggregates of β-2-microglobulin in live macrophages and detected by Flow Cytometry.
Do you want to learn more? Read the publication here.
Image: The structure of β-2-microglobulin in its native and fibrillar states. Image from Figure 4 AB by Iadanza et al. (2018) Nature Communications, 9(1), 4517 (CC BY 4.0).